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New technology to tackle treatment-resistant cancers

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New technology to tackle treatment-resistant cancers

Free-flowing cancer cells have been mapped with unprecedented accuracy in the bloodstream of patients with prostate, breast and pancreatic cancer, using a brand new approach, in an attempt to assess and control the disease as it spreads in real time through the body, and solve the problem of predicting response and resistance to therapies.

In comparison to a previous generation of systems, the researchers state their test showed a significantly greater number of high-definition circulating tumour cells (HD-CTCs), in a higher proportion of patients, by using a computing-intensive method that enables them to look at millions of normal cells and find the rare cancer cells among them.

Their results published in IOP Publishing's journal Physical Biology, could help reveal the mechanisms behind the spread of solid tumours from one organ or tissue to another - mechanisms that have, until now, remained a mystery.

Dr Jorge Nieva, an oncologist at Billings Clinic leading the study, said: "This technology will allow scientists to move away from mouse and cell culture systems and speed the delivery of cures for cancer in people. This is the technology we have been waiting for to solve the problem of resistance to chemotherapy drugs."

Senior technology author of the study, Professor Peter Kuhn, said: "In the future, our fluid biopsy can effectively become the companion to the patient for life. If we can assess the disease in real time, we can make quantitative treatment decisions in real time. These decisions include predictive decisions about therapeutic response, diagnostic decisions and prognostic decisions about outcome."

The researchers, based at the Scripps Physics Oncology Center in La Jolla, California, were able to find five or more CTCs in each milliliter of blood in 80% of the 20 patients they tested with prostate cancer; 70% in the 30 patients with breast cancer; and 50% in the 18 patients with pancreatic cancer.

The authors also report that their test showed significantly better results when compared with the commercial test, CellSearch®, which uses a slightly less accurate approach which effectively reduces the sample from approximately 50 million cells to just 5,000 before conducting fluorescent imaging, meaning important cells you wish to study could be lost.

(worldpharmanews.com)

Last Updated on Tuesday, 02 February 2016 08:51  

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Editorial Board

  • Professor Lilian M. Azzopardi
    Department of Pharmacy,
    University of Malta,
    Malta

    Professor Karim A. Alkadhi
    Department of Pharmacological and Pharmaceutical Sciences,
    University of Houston,
    Houston, USA

    Dr. Poonam Singh
    Scientist, Division of Toxicology,
    Central Drug Research Institute,
    India

    Dr. Jason Eriksen
    Department of Pharmacological and Pharmaceutical Sciences,
    University of Houston,
    Houston, USA

    Professor V. Kusum Devi
    Department of Pharmaceutics,
    Al-Ameen College of Pharmacy,
    Bangalore, India

    Associate Professor Bruce Charles
    Pharmacy Australia Centre of Excellence,
    School of Pharmacy, The University of Queensland,
    Brisbane, Australia

    Dr. Karem Alzoubi
    Assistant Dean, Faculty of Pharmacy,
    Jordan University of Science and Technology,
    Jordan

    Professor Nurten ├ľzdemir
    Faculty of Pharmacy, Ankara University,
    Ankara, Turkey

    Dr. Veena S. Nukoolkarn
    Department of Pharmacognosy,
    Faculty of Pharmacy, Mahidol University,
    Phyathai, Bangkok

    Dr. Ajay Sharma
    Mason Eye Institute,
    University of Missouri,
    Columbia,
    MO, United States

    Professor Olobayo O Kunle
    Director, Department of Pharmaceutical Technology and Raw Material Development,
    National Institute of Pharmaceutical Research and Development (NIPRD),
    Idu, Abuja, Nigeria

    Okoro Roland Nnaemeka
    Department of Clinical Pharmacy and Pharmacy Administration,
    University of Maiduguri,
    Maiduguri, Borno State, Nigeria

    Dr. Manoj Sharma
    Principal, Shri R N S College of Pharmacy,
    Gormi, Bhind, Madhya Pradesh, India

    Professor Dhrubo Jyoti Sen
    Department of Pharmaceutical Chemistry,
    Shri Sarvajanik Pharmacy
    College,
    Mehsana, Gujarat, India

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