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USPTO grants patent for ARIAD Pharma's ponatinib

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USPTO grants patent for ARIAD Pharma's ponatinib

The United States Patent and Trademark Office (USPTO) has granted US Patent No. 8,114,874  to ARIAD Pharmaceuticals Inc., entitled, “Substituted Acetylenic Imidazo[1,2-B] Pyridazine Compounds as Kinase Inhibitors,” which provides composition-of-matter patent protection through at least December 22, 2026 for ARIAD’s investigational pan-BCR-ABL inhibitor, ponatinib.

This new patent covers both the compound itself and its pharmaceutical compositions. Additional patent applications covering ponatinib in the US and in other countries are pending.

“We are delighted that the US Patent Office has acknowledged that the chemical space pioneered by our scientists and reflected by ponatinib is innovative and worthy of patent protection. We are preparing to file for US and European marketing authorizations of ponatinib in patients with resistant or intolerant chronic myeloid leukaemia and Philadelphia-chromosome positive acute lymphoblastic leukaemia in the third quarter of this year,” stated Harvey J Berger, MD, chairman and chief executive officer of ARIAD.

Ponatinib is an investigational pan-BCR-ABL inhibitor discovered by ARIAD scientists. BCR-ABL is an abnormal tyrosine kinase that is expressed in patients with CML and Philadelphia chromosome-positive acute lymphoblastic leukaemia (Ph+ ALL). Using ARIAD’s computational and structure-based drug design platform, ponatinib was designed to inhibit the activity of BCR-ABL with very high potency and broad specificity. Ponatinib targets not only native BCR-ABL but also its mutant isoforms that confer resistance to existing tyrosine kinase inhibitors, including the T315I mutation for which no effective therapy exists. Ponatinib is currently being evaluated in the pivotal phase II PACE trial in patients with resistant or intolerant CML and Ph+ ALL. Ponatinib also inhibits certain other tyrosine kinases, including FLT3, which is aberrantly activated in approximately one-third of patients with AML and the FGFR family of kinases, which are activated in subsets of patients with solid tumours.ARIAD Pharmaceuticals, Inc. is focused on the discovery, development and commercialization of medicines to transform the lives of cancer patients.

(www.pharmabiz.com)

Last Updated on Tuesday, 02 February 2016 08:50  

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  • Professor Lilian M. Azzopardi
    Department of Pharmacy,
    University of Malta,
    Malta

    Professor Karim A. Alkadhi
    Department of Pharmacological and Pharmaceutical Sciences,
    University of Houston,
    Houston, USA

    Dr. Poonam Singh
    Scientist, Division of Toxicology,
    Central Drug Research Institute,
    India

    Dr. Jason Eriksen
    Department of Pharmacological and Pharmaceutical Sciences,
    University of Houston,
    Houston, USA

    Professor V. Kusum Devi
    Department of Pharmaceutics,
    Al-Ameen College of Pharmacy,
    Bangalore, India

    Associate Professor Bruce Charles
    Pharmacy Australia Centre of Excellence,
    School of Pharmacy, The University of Queensland,
    Brisbane, Australia

    Dr. Karem Alzoubi
    Assistant Dean, Faculty of Pharmacy,
    Jordan University of Science and Technology,
    Jordan

    Professor Nurten Özdemir
    Faculty of Pharmacy, Ankara University,
    Ankara, Turkey

    Dr. Veena S. Nukoolkarn
    Department of Pharmacognosy,
    Faculty of Pharmacy, Mahidol University,
    Phyathai, Bangkok

    Dr. Ajay Sharma
    Mason Eye Institute,
    University of Missouri,
    Columbia,
    MO, United States

    Professor Olobayo O Kunle
    Director, Department of Pharmaceutical Technology and Raw Material Development,
    National Institute of Pharmaceutical Research and Development (NIPRD),
    Idu, Abuja, Nigeria

    Okoro Roland Nnaemeka
    Department of Clinical Pharmacy and Pharmacy Administration,
    University of Maiduguri,
    Maiduguri, Borno State, Nigeria

    Dr. Manoj Sharma
    Principal, Shri R N S College of Pharmacy,
    Gormi, Bhind, Madhya Pradesh, India

    Professor Dhrubo Jyoti Sen
    Department of Pharmaceutical Chemistry,
    Shri Sarvajanik Pharmacy
    College,
    Mehsana, Gujarat, India

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