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Home Archive Volume 08,Issue 01,Year 2017
Volume 08,Issue 01,Year 2017

Volume 08,Issue 01,Year 2017

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Review article

Shubhankar Saha*, Pranabesh Sikdar, D. Lavanya, M. Niranajan Babu

Department of Pharmacology, Department of Pharmaceutical Chemistry, Seven Hills College of Pharmacy, Tirupati, Andhra Pradesh, India


Abstract:

Hepatitis means inflammation of the liver. The liver is just one of several organs that the viruses affect. There are several hepatitis viruses; they have been named types A, B, C, D, E and G. The most common types of viral hepatitis are HAV, HBV and HCV. The different hepatitis are transmitted by various routes such as parenteral transmission, sexual transmission, sporadic cases, transmission via blood transfusion. There are some non viral causes such as parental transmission, alcohol. The different sign and symptoms observed in the hepatitis are fatigue flu-like symptoms dark urine pale stool abdominal pain loss of appetite. Hepatitis can be diagnosed in different methods such as Physical Exam, Liver Biopsy, Liver Function Tests, Ultrasound, Blood Tests and Viral Antibody Testing. Hepatitis vaccines are generally used to control the hepatitis caused by different modes.

Keywords: Hepatitis, Liver, Chronic Hepatitis A, Hepatitis B, Hepatitis C


Address reprint: Shubhankar Saha* Department of Pharmacology, Department of Pharmaceutical Chemistry, Seven Hills College of Pharmacy, Tirupati, Andhra Pradesh, India

Published under Creative Commons Attribution (CC BY) license

Research article

Sabah J. Salih*

Ministry of health, National Center of Drug Control and Research (NCDCR) Baghdad-IRAQ

Abstract
New water-soluble, prodrugs ester of Betamethasone was synthesized. Its partition coefficients revealed its colon targeting. This new compound is (2R,2'R)- ((8S,9R, 10R,11R,13S,14R,16S,17S)- 9-fluoro-10, 13, 16-trimethyl-3-oxo-17-(2-((R)-5-oxotetrahydrofuran-2-carbonyloxy)acetyl)-6,7,8,9,10,11,12,13,14,15,16, 17-dodecahydro-3H-cyclopenta[a] phenanthrene-11, 17-diyl) bis (5-oxotetrahydrofuran-2-carboxylate) (compound II). Its enhancement in lipid solubility, comparing to betamethasone, means rapid absorbance through different membranes.

Keywords: Dexamethasone, prednisolone, prodrugs, tetrahydrofuran, thiazolidine and glutamic acid.

Address reprint: Sabah J. Salih, Ph.D. Pharm. Chem. Ministry of health, National Center of Drug Control and Research (NCDCR) Baghdad-IRAQ

Published under Creative Commons Attribution (CC BY) license

Research article

Nagendra R*, Charan CS, K. Hanumanthachar Joshi, Jayanthi C

Department of Pharmaceutics, Sarada Vilas College of Pharmacy Mysuru, Karnataka, India

Abstract:

The present study aimed at preparation and evaluation of microparticles for controlled release of sotalol hydrochloride in the treatment of arrhythmia. Sotalol has both beta-adrenoreceptor blocking and cardiac action potential duration prolongation and antiarrhythmic properties. The microparticles of sotalol hydrochloride were prepared by solvent evaporation method .The prepared microparticles were evaluated for drug polymer compatibility, the results shown that there were no significant interactions. The encapsulation efficacy was ranging from 66-85%. The in-vitro drug release studies indicate the release of drug in a controlled manner over a period of 12 hrs. It was found that the Sotalol Hydrochloride release rate increased with a decreased amount of Ethyl Cellulose since the drug is water soluble. This can be adjusted by maintaining the concentration of the polymers. The formulation F4 was found to be optimum formulation.

Keywords: Sotalol Hydrochloride, Arrhythmia, Ethyl Cellulose, Controlled release

Address reprint: Nagendra.R Department of Pharmaceutics, Sarada Vilas College of Pharmacy Mysuru, Karnataka

Published under Creative Commons Attribution (CC BY) license

Research article

Ahmed Ismail Alshather*

Ministry of health, National Center of Drug Control and Research (NCDCR) Baghdad-Iraq

Abstract:

Prodrugs design and prepare as a new polymeric anticancer prodrugs, by using dextran and a group of chemotherapeutics agents. Some of these prodrugs contained ester links, others had imine or carbamate links. The preparation required series of chemical reactions such as esterfication, imination and carbamation. Preliminary kinetic studies that comprised hydrolysis in miscellaneous acidic media showed that imine bond in the possible prodrugs hydrolysed and liberated the chemotherapeutic agent faster in acidic media which comparable with acidity of neoplastic tissues. While, the hydrolysis of ester and carbamate possible prodrugs were relatively slow in these acidic media.

Keywords: Cancer, drug delivery, dextran.

 

Address reprint: Ahmed Ismail Alshather; Ph. D. Pharm. Chem. Ministry of health, National Center of Drug Control and Research (NCDCR) Baghdad-Iraq

Published under Creative Commons Attribution (CC BY) license

Research article

Chaitra G*,Vageesh VM, Jayanthi C, KHanumanthachar Joshi

Department of Pharmaceutics, Sarada Vilas College of Pharmacy Mysuru, Karnataka, India

Abstract:

Microsponge technology has been introduced in topical drug products to facilitate the controlled release of active drug into the skin in order to reduce systemic exposure and minimize local cutaneous reactions to active drugs. Microsponge consists of macroporous beads, typically 10-25?m in diameter, loaded with active agent. When applied to the skin, the microsponge releases its active ingredients on a time mode and also in response to other stimuli. Microsponge drug delivery technology holds a great promise for reaching the goal of controlled and site-specific drug delivery and hence, has attracted wide attention of researchers. This article presents a broad review of Microsponges delivery system discussing the principles and preparation methods. Appropriate analytical techniques for characterization of Microsponges like Particle size and its distribution, surface morphology, porosity, density are covered. These microsponges are used in the sunscreens, creams, ointments, over-the-counter skin care preparations, which are meant for topical application. Microsponge drug delivery can provide increased efficacy for topically active agents with enhanced safety, extended product stability and improved aesthetic properties in an efficient and novel manner. They are mostly used for topical use and have recently been used for oral administration.

Keywords: Microsponge, MDS, controlled release, Topical drug delivery,Liquid-Liquid Suspension Polymerization, Quasiemulsion method.

 

Address reprint: Chaitra G. Department of Pharmaceutics, Sarada Vilas College of Pharmacy Mysuru, Karnataka, India

Published under Creative Commons Attribution (CC BY) license

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