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Home Archive Hepato-Protective Activity of Plumbago Zeylanica against Diethylnitrosamine Induced Liver Damage in Male Wistar Albino Rats- A Chronic Study
Details for Hepato-Protective Activity of Plumbago Zeylanica against Diethylnitrosamine Induced Liver Damage in Male Wistar Albino Rats- A Chronic Study
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NameHepato-Protective Activity of Plumbago Zeylanica against Diethylnitrosamine Induced Liver Damage in Male Wistar Albino Rats- A Chronic Study
Description

Original article

Sivakumar Vijayaraghavalu* and Niranjali Devaraj, S

Department of Biochemistry, University of Madras, Guindy Campus, Chennai, 600025, India

Abstract:

Plumbago zeylanica, a widely used oriental herb in traditional medical systems across Asia was tested for its hepato-protective activity against diethylnitrosamine (DENA) induced liver damage in male wistar albino rats. DENA induced liver damage/hepatocarcinogensis is well accepted model to assess the in vivo anticancer activity of drugs and herbal extracts. For experimental purpose the rats were divided into four groups of six animals each. Liver damage was induced in a group of rats (positive control) by administering 200 ppm DENA in drinking water for 90 consecutive days. Treatment group received both DENA in drinking water and alcoholic root extract of Plumbago zeylanica (500 mg/kg b.wt.) by oral gavage for 90 days. Another group of animals received only the root extract and the animals that left untreated served as negative control. Results of this study shown a significant increase in tumor markers such as alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA) and 5?? nucleotidase in serum of DENA alone treated animals on comparison to negative control. Contrarily, the treatment group showed lower levels of tumor markers in serum when compared with positive control. Results were comparable between the animals that received only root extract and untreated animals. Conclusively, this study demonstrated the hepato-protective nature of alcoholic root extract of Plumbago zeylanica against chemical carcinogen induced liver damage.

Keywords: DENA, Diethylnitrosamine, AFP, CEA, Liver damage, Hepatocellular carcinoma, Plumbago zeylanica, Chemical carcinogen.

Address reprint to: *Sivakumar Vijayaraghavalu, Ph.D.

Department of Biochemistry, University of Madras, Guindy Campus, Chennai, 600025, India

Email: livshiva@gmail.com

Published under Creative Commons Attribution (CC BY) license.

FilenameIJCP_Sivakumar Vol 08, Isssue 04,year 2017_81-86...pdf
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Created On: 08/28/2017 00:00
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